
Clorazepate (Tranxene) Tapering: A Slow, Supervised Approach
What is clorazepate, and why does it last so long in the body? Clorazepate, sold under the brand name Tranxene, is a long-acting benzodiazepine. Benzodiazepines…

Mark Leeds, D.O. is an osteopathic physician and deprescribing specialist in Fort Lauderdale, Florida. He helps patients come off benzodiazepines and sleeping pills with a slow, patient-directed taper guided by the Ashton Manual and the Maudsley Deprescribing Guidelines. Physical dependence is not addiction, and a careful taper is measured in months, not days.

What is clorazepate, and why does it last so long in the body? Clorazepate, sold under the brand name Tranxene, is a long-acting benzodiazepine. Benzodiazepines…

What is Sonata, and why does a benzodiazepine website cover it? Sonata, or zaleplon, is a prescription sleeping pill. Its label from the United States…

Dalmane is a benzodiazepine sleeping medication, and it produces the same physical dependence as any other. Dalmane is the brand name for flurazepam, a hypnotic…

Why is triazolam (Halcion) so hard to stop? Triazolam, sold as Halcion, is a benzodiazepine sleeping pill, and it is one of the shortest-acting members…

Key Takeaways Oxazepam is the generic name of the benzodiazepine once sold as Serax, so a patient coming off of either name is tapering the…

Key Takeaways Temazepam, sold as Restoril, is a benzodiazepine sleeping pill indicated for short-term use, and years of nightly use produce physical dependence even when…

Key Takeaways Lunesta (eszopiclone) is not a benzodiazepine, but it acts at the same gamma-aminobutyric acid (GABA) receptor complex, so nightly use produces the same…

Key Takeaways Zolpidem, sold as Ambien, is a z-drug rather than a benzodiazepine by chemistry, but it acts at the same GABA-A receptor, so it…

Key Takeaways Clonazepam (Klonopin) taken steadily for months or years produces physical dependence, which is a medical condition caused by a medication and not addiction.…

Key Takeaways Lorazepam (Ativan) taken every day for months or years produces physical dependence even at prescribed doses, and physical dependence is not addiction. Lorazepam…

Key Takeaways Daily Valium (diazepam) use for more than a few weeks can cause physical dependence, which is a medical condition and not addiction, and…

Key Takeaways Xanax (alprazolam) is tapered slowly, in small steps, over months, with a prescriber who understands the drug. Feeling ill when a dose is…